van Amerongen Lab - Developmental, Stem Cell & Cancer Biology

- Swammerdam Institute for Life Sciences - University of Amsterdam -  


PhD theses

peer-reviewed papers and preprints

Contributions from lab members are shown in bold. An asterisk (*) indicates an equal contribution/shared authorship. Contributions from BSc and MSc students are underlined.

Mourao L*, Zeeman AL*, Wiese KE, Bongaarts A, Oudejans LL, Mora Martinez I, van de Grift YBC, Jonkers J, van Amerongen R (202x), 'Hyperactive WNT/CTNNB1 signaling induces a competing cell proliferation and epidermal differentiation response in the mouse mammary epithelium', Biorxiv (2021)

Heijmans N*, Wiese KE*, Jonkers J,R van Amerongen (202x), 'Transcriptomic analysis of pubertal and adult virgin mouse mammary epithelial and stromal cell populations', Biorxiv (2024)

CY Feigin, JA Moreno, R Ramos, SA Mereby, A Alivisatos, W Wang, R van Amerongen, J Camacho, JJ Rasweiler, R Behringer, B Ostrow, MV Plikus, R Mallarino (2023), 'Convergent deployment of ancestral programs during the evolution of mammalian flight membranes', Science Advances 9(12): DOI: 10.1126/sciadv.ade7511 (first available as pre-print)

van Boxtel AL (2023), 'Whole-Mount In Situ Hybridization for Detection of Migrating Zebrafish Endodermal Cells', Methods Mol Biol. 2023;2608:131-145. doi: 10.1007/978-1-0716-2887-4_9.

van der Wal T, van Amerongen R (2023), 'Visualizing WNT signaling in mammalian systems', Curr Top Dev Biol. 2023;153:61-93. doi: 10.1016/bs.ctdb.2023.02.001. Epub 2023 Mar 16.

van Amerongen R, Bentires-Alj M, van Boxtel AL, Clarke RB, Fre S, Gonzalez Suarez E, Iggo R, Jechlinger M, Jonkers J, Mikkola ML, Sumbalova Koledova Z, Sørlie T, dM Vivanco M (2023), 'Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research', J Mammary Gland Biol Neoplasia. 2023 Jul 14;28(1):17 doi: 10.1007/s10911-023-09544-y direct link to the PDF here

Chalmers SB, van der Wal T, Fre S, Jonkers J (2023), 'Fourteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer', J Mammary Gland Biol Neoplasia. 2023 Oct 6;28(1):22. doi: 10.1007/s10911-023-09549-7.

Aarts MT, Wagner M, van der Wal T, van Boxtel AL*, van Amerongen R* (2023), 'A molecular toolbox to study progesterone receptor signaling ', J Mammary Gland Biol Neoplasia 28, 24 (2023). (first available as a pre-print)

Kaiser K, Jang A, Lun M, Prochazka J, Machon O, Prochazkova M, Laurent B, Gyllborg D, van Amerongen R, Kompanikova P, Wu F, Barker RA, Uramova I, Sedlacek R, Kozmik Z, Arenas E, Lehtinen MK, Bryja V (2021), 'MEIS-WNT5A axis regulates development of 4th ventricle choroid plexus', Development (2021) 148 (10): dev192054.

(first available as a pre-print)

De Man SMA, Zwanenburg G, van der Wal T, Hink MA*, van Amerongen R* (2021), 'Quantitative live-cell imaging and computational modelling shed new light on endogenous WNT/CTNNB1 signaling dynamics', eLife 2021;10:e66440
(first available as pre-print)

van de Grift YBC, Heijmans N, van Amerongen R (2021), 'How to use online tools to generate new hypotheses for mammary gland biology research: a case study for Wnt7b', J Mammary Gland Biol Neoplasia (2021).

(first available as a pre-print)

van Amerongen R (2021), 'Behind the Scenes of the Human Breast Cell Atlas Project', Journal of Mammary Gland Biology and Neoplasia https://10.1007/s10911-021-09482-7

SMA de Man, R van Amerongen (2021), 'Zooming in on the WNT/CTNNB1 Destruction Complex: Functional Mechanistic Details with Implications for Therapeutic Targeting ', Handbook of Experimental Pharmacology. Springer, Berlin, Heidelberg.

van der Linden, FH, Mahlandt EK, Arts JJ, Beumer J, Puschhof J, de Man SMA, Chertkova AO, Ponsioen B, Clevers H, van Buul JD, Postma M, Gadella, TWJ Jr. & Goedhart, J. (2021), 'A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium.', Nature Communications, 12(1), 7159.

van der Wal T, Lambooij JP, van Amerongen R (2020), 'TMEM98 is a negative regulator of FRAT mediated Wnt/β-catenin signalling', PLoS One. 2020 Jan 21;15(1):e0227435. doi: 10.1371/journal.pone.0227435. eCollection 2020.
(first available as a pre-print)

van Schie EH, van Amerongen R (2020), 'Aberrant WNT/CTNNB1 Signaling as a Therapeutic Target in Human Breast Cancer: Weighing the Evidence', Front. Cell Dev. Biol., 31 January 2020 |

van Amerongen R (2020), 'Celebrating Discoveries in Wnt Signaling: How One Man Gave Wings to an Entire Field', Cell, first vailable online 31 March 2020.

van de Moosdijk AAA*, van de Grift YBC*, de Man SMA, Zeeman AL, van Amerongen R (2020), 'A novel Axin2 knock-in mouse model for visualization and lineage tracing of WNT/CTNNB1 responsive cells', genesis 2020;e23387.
(first available as a pre-print)

van der Wal A, van Amerongen R (2020), 'Walking the tight wire between cell adhesion and WNT signalling: a balancing act for CTNNB1', Open Biology 10(12)

Wiese KE, Nusse R, van Amerongen R (2018), 'Wnt signalling: conquering complexity', Development 2018 145: dev165902 doi: 10.1242/dev.165902 Published 26 June 2018

van de Moosdijk AA, Fu NY, Rios AC, Visvader JE, van Amerongen R (2017), 'Lineage Tracing of Mammary Stem and Progenitor Cells', Methods Mol Biol. 2017;1501:291-308

Wiese KE, Amante RJ, Vivanco MD, Bentires-Alj M, Iggo RD (2017), 'The ninth ENBDC Weggis meeting: growth and in-depth characterisation of normal and neoplastic breast cells.', Breast Cancer Res. 2017 Aug 22;19(1):96. doi: 10.1186/s13058-017-0891-9

Bindels DS, Haarbosch L, van Weeren L, Postma M, Wiese KE, Mastop M, Aumonier S, Gotthard G, Royant A, Hink MA, Gadella TW Jr. (2017), 'mScarlet: a bright monomeric red fluorescent protein for cellular imaging', Nat Methods. 2017 Jan;14(1):53-56. doi: 10.1038/nmeth.4074. Epub 2016 Nov 21.

Jacobsen A., Heijmans N., Verkaar F., Smit M.J., Heringa J., van Amerongen R.*, Feenstra K.A.* (2016), 'Construction and Experimental Validation of a Petri Net Model of Wnt/β-Catenin Signaling', PLoS ONE 11 (5): e0155743. doi:10.1371/journal.pone.0155743

MC Boelens, M Nethe, S Klarenbeek, JR de Ruiter, E Schut, N Bonzanni, AL Zeeman, E Wientjens, E van der Burg, L Wessels, R van Amerongen, J Jonkers (2016), 'PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma', Cell Reports 16(8): 2087–2101

Loh KM, van Amerongen R, Nusse R (2016), 'Generating cellular diversity and spatial form: Wnt Signaling and the Evolution of Multicellular Animals', Developmental Cell 38(6): p643–655

van de Moosdijk AAA, van Amerongen R (2016), 'Identification of reliable reference genes for qRT-PCR studies of the developing mouse mammary gland', Scientific Reports 6:35595 DOI: 10.1038/srep35595

Lloyd-Lewis B, van de Moosdijk AAA, Bentires-Alj M, Clarke RB, van Amerongen R (2016), 'Complexity galore: 3D cultures, biomechanics and systems medicine at the eighth ENBDC workshop “Methods in Mammary Gland Development and Cancer”', Breast Cancer Res (2016) 18: 115.

van Amerongen R (2015), 'Lineage Tracing in the Mammary Gland Using Cre/lox Technology and Fluorescent Reporter Alleles', Methods Mol Biol. 2015;1293:187-211

Glukhova MA, Hynes N, Vivanco M dM, van Amerongen R, Clarke RB and Bentires-Alj M (2015), 'The seventh ENBDC workshop on methods in mammary gland development and cancer', Breast Cancer Research 17:119

Green J, Nusse R, van Amerongen R (2014), 'The role of ryk and ror receptor tyrosine kinases in wnt signal transduction.', Cold Spring Harb Perspect Biol. 2014 Feb 1;6(2). pii: a009175.

Rinkevich Y, Montoro DT, Contreras-Trujillo H, Harari-Steinberg O, Newman AM, Tsai JM, Lim X, Van-Amerongen R, Bowman A, Januszyk M, Pleniceanu O, Nusse R, Longaker MT, Weissman IL, Dekel B. (2014), 'In Vivo Clonal Analysis Reveals Lineage-Restricted Progenitor Characteristics in Mammalian Kidney Development, Maintenance, and Regeneration', Cell Rep. 2014 May 22;7(4):1270-83.

Shehata M, van Amerongen R, Zeeman AL, Giraddi RR, Stingl J (2014), 'The influence of tamoxifen on normal mouse mammary gland homeostasis', Breast Cancer Research 2014, 16:411

Kemper K, de Goeje PL, Peeper DS, van Amerongen R (2014), 'Phenotype Switching: Tumor Cell Plasticity as a Resistance Mechanism and Target for Therapy', Cancer Res. 2014 Nov 1;74(21):5937-41. Epub 2014 Oct 15.

van Amerongen R (2014), 'Bipotent mammary stem cells: now in amazing 3D', Breast Cancer Research 2014, 16:480

prior to 2014
van Amerongen, R and Berns, A (2013), 'Break the loop, escape the cycle?', EMBO J 32(14): 1967-1969

Lim, X., S. H. Tan, W. L. Koh, R. M. Chau, K. S. Yan, C. J. Kuo, R. van Amerongen, A. M. Klein and R. Nusse (2013), 'Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling ', Science 342(6163): 1226-1230

Volkenstein, S., K. Oshima, S. T. Sinkkonen, C. E. Corrales, S. P. Most, R. Chai, T. A. Jan, R. van Amerongen, A. G. Cheng and S. Heller (2013), 'Transient, afferent input-dependent, postnatal niche for neural progenitor cells in the cochlear nucleus.', Proc Natl Acad Sci U S A 110(35): 14456-14461.

Jan, T. A., R. Chai, Z. N. Sayyid, R. van Amerongen, A. Xia, T. Wang, S. T. Sinkkonen, Y. A. Zeng, J. R. Levin, S. Heller, R. Nusse and A. G. Cheng (2013), 'Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells.', Development 140(6): 1196-1206.

Bowman, A. N., van Amerongen, R, Palmer, TD and Nusse, R (2013), 'Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/beta-catenin-responsive neural stem cells.', Proc Natl Acad Sci U S A 110(18): 7324-7329.

van Amerongen, R., A. N. Bowman and R. Nusse (2012), 'Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland.', Cell Stem Cell 11(3): 387-400.

van Amerongen, R., C. Fuerer, M. Mizutani and R. Nusse (2012), 'Wnt5a can both activate and repress Wnt/beta-catenin signaling during mouse embryonic development.', Dev Biol 369(1): 101-114.

van Amerongen, R. (2012), 'Alternative Wnt pathways and receptors.', Cold Spring Harb Perspect Biol 4(10).

Verkaar, F., K. M. Cadigan and R. van Amerongen (2012), 'Celebrating 30 years of Wnt signaling.', Sci Signal 5(254): mr2.

Walf-Vorderwulbecke, V., J. de Boer, S. J. Horton, R. van Amerongen, N. Proost, A. Berns and O. Williams (2012), 'Frat2 mediates the oncogenic activation of Rac by MLL fusions.', Blood 120(24): 4819-4828.

van Amerongen, R., M. C. Nawijn, J. P. Lambooij, N. Proost, J. Jonkers and A. Berns (2010), 'Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways.', Oncogene 29(1): 93-104.

van Amerongen, R. and R. Nusse (2009), 'Towards an integrated view of Wnt signaling in development.', Development 136(19): 3205-3214.

van Amerongen, R., A. Mikels and R. Nusse (2008), 'Alternative wnt signaling is initiated by distinct receptors.', Sci Signal 1(35): re9.

van Amerongen, R. and A. Berns (2008), 'Targeted anticancer therapies: mouse models help uncover the mechanisms of tumor escape.', Cancer Cell 13(1): 5-7.

van Amerongen, R. and A. Berns (2006), 'TXR1-mediated thrombospondin repression: a novel mechanism of resistance to taxanes?', Genes Dev 20(15): 1975-1981.

van Amerongen, R. and A. Berns (2006), 'Knockout mouse models to study Wnt signal transduction.', Trends Genet 22(12): 678-689.

van Amerongen, R. and A. Berns (2005), 'Re-evaluating the role of Frat in Wnt-signal transduction.', Cell Cycle 4(8): 1065-1072.

van Amerongen, R., M. Nawijn, J. Franca-Koh, J. Zevenhoven, H. van der Gulden, J. Jonkers and A. Berns (2005), 'Frat is dispensable for canonical Wnt signaling in mammals.', Genes Dev 19(4): 425-430.

van Amerongen, R., H. van der Gulden, F. Bleeker, J. Jonkers and A. Berns (2004), 'Characterization and functional analysis of the murine Frat2 gene.', J Biol Chem 279(26): 26967-26974.

Scheffer, G. L., A. W. Reurs, B. Jutten, S. H. Beiboer, R. van Amerongen, M. Schoester, E. A. Wiemer, H. R. Hoogenboom and R. J. Scheper (2002), 'Selection and characterisation of a phage-displayed human antibody (Fab) reactive to the lung resistance-related major vault protein.', Br J Cancer 86(6): 954-962.

Chan, M. F.*, R. van Amerongen*, T. Nijjar, E. Cuppen, P. A. Jones and P. W. Laird (2001), 'Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells.', Mol Cell Biol 21(22): 7587-7600.

Jonkers, J., R. van Amerongen, M. van der Valk, E. Robanus-Maandag, M. Molenaar, O. Destree and A. Berns (1999), 'In vivo analysis of Frat1 deficiency suggests compensatory activity of Frat3.', Mech Dev 88(2): 183-194.